Arabic gum on indomethacin induced gastric ulcer in male rats. Gastroprotective effects of fermented lotus root against. In this regard, an animal model experiment was carriedout to determine the ulcerdose of indomethacin on female wistar rats. The gastric mucosa is continuously exposed to various agents like food condiments, spices, alcohol, acids and. In fact, no acid, no ulcer is the dictum for duodenal ulcer. The results showed that indomethacin induced gastric ulcer ulcer index 2900, was associated with a significant increase of tumor necrosis factoralpha and malondialdehyde, and significant decrease of the gastroprotective mediators prostaglandin e2. The histopathology of indomethacin induced antral ulcers 3. Many idminduced ulcers were shown 24 hours after the injection of idm at a dose of 10mgkg. After 24 h, all the animals were sacrificed and the duodena were excised carefully and cut.
At the end of the experiment, gastric secretions and. Jan 19, 2010 indomethacin is an indol derivative, nonsteroidal, antiinflammatory drug with antiinflammatory, analgesic, and antipyretic effects. Indomethacin belongs to a group of medicines known as nsaids nonsteroidal anti. Abstract the anti ulcer activity of hydro alcoholic extract of rhus coriaria linn haerc was investigated in indomethacin and water immersion induced restraint gastric ulcer in wistar rats. Gastric ulcer induced by pyloric ligation is believed to be due to stress induced increased in gastric hydrochloric acid secretion andor stasis of acid. Black tea extracts on indomethacin induced testicular histopathology 54 journal of young pharmacists vol 6 issue 3 julsep 2014 indomethacin is a nsaid drug and associated with several sideeffect like nausea, vomiting, diarrhea, constipation. Nevertheless, some drugs that arrest ulcer progression have been reported to heal or prevent indomethacininduced ulcer without affecting these molecules above. The fruit pulp was extracted with ethanol and the antiulcer activity of the extract in indomethacininduced gastric ulceration in swiss albino rats was.
Nsaids should be prescribed with extreme caution in those with prior history of ulcer disease or gastrointestinal bleeding. Department of physiology, college of medicine, university of ibadan, ibadan, nigeria. In the gastric ulcer models induced by ethanol and cold restraintstress the previous treatment with emn at dose of 300. A study on the mechanism of indomethacin induced intestinal ulcer. Indomethacin is a potent nonsteroidal antiinflammatory drug nsaid typically used for chronic inflammatory arthritis.
Eighteen female rats 225 25 g body weight were randomly assigned to 3 groups under standard laboratory condition. This study was performed to determine the antiulcer effects of ethanol extract of parkia speciosa on indomethacin induced peptic ulcer in albino rats. Nsaids cause increased risk of serious gi inflammation, ulceration, bleeding, and perforation may be fatal. Gastric ulcer has shown association with changes in sex hormones, with impact exacerbated in males. Proulcer effects of resveratrol in mice with indomethacininduced gastric ulcers are reversed by larginine. Antiulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats adewoye e. The first page of the pdf of this article appears above. Gastric juice, gastric mucosa, morphologies of gastric ulcers and protein. Patients with a prior history of peptic ulcer disease andor gastrointestinal bleeding who use nsaids have a greater than 10fold increased risk for developing a gi bleed compared to patients with neither of these risk factors. Enhanced antiulcer effect of pioglitazone on gastric. The gastric damage induced by indomethacin occurred linearly along the long axis of the stomach, and microscopically, was seen at the top or the bottom of mucosal foldings, the sites most influenced by mucosal compression due to contraction of the stomach, where mucosal blood flow is restricted. The healing activities of black tea bt and the theaflavins tf against the indomethacininduced stomach ulceration were studied in a mouse model. Many idm induced ulcers were shown 24 hours after the injection of idm at a dose of 10mgkg.
The effect of different extracts of leaves and fruits of moringa oleifera lam. Gastroprotective effect of nicorandil in indomethacin and. Uptodate, electronic clinical resource tool for physicians and patients that provides information on adult primary care and internal medicine, allergy and immunology, cardiovascular medicine, emergency medicine, endocrinology and diabetes, family medicine, gastroenterology and hepatology, hematology, infectious diseases, nephrology and. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical received for publication, october 9, 2002, and in revised form, january 6, 2003 published, jbc papers in press, january 15, 2003, doi 10. The effects of aqueous leaf extracts of sm and fe on the ulcer index and % inhibition against ulcer in the experimental animals are shown in fig. In this study, we showed that nimesulide 100, 300, 500 mgkg prevented the indomethacin induced gastric ulcers completely. Pdf gastroprotective effect of vanillin on indomethacin. Black tea extract ameliorates indomethacin induced changes. Indomethacininduced gastric antral ulcers in hamsters. This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacin induced gastric ulcer in rats. Gastric ulcer, ethanol, indomethacin, minocycline, oxidative stress, myeloperoxidase introduction. Indomethacin is a nonsteroidal antiinflammatory drug, used in the treatment of many inflammatory diseases. An alcoholinduced gastric ulcer model has been commonly. The gastroprotective effect of memora nodosa roots against.
Fruit pulp extract on indomethacininduced gastric ulcer in albino. Rizophoraceae against cimetidine on gastric ulceration induced by ethanol. Antiulcer activity of ethanol extract of parkia speciosa against indomethacin induced peptic ulcer in albino rats abstract. The mini gastric bypass mgb is a short, simple, successful, reversible laparoscopic gastric bypass weight loss surgery. Elgohary 4 department of physiology 5 faculty of medicine, benha university, benha, egypt 6 7 8 1. The role of endoscopy in the management of patients with.
Delayed healing of acetic acidinduced gastric ulcers in. Because 30% of patients having duodenal ulcer and very few patients with gastric ulcer are. All animals were maintained and used in accordance with the guidelines issued. A peptic ulcer is a defect in the gastric or duodenal wall that extends through. Black tea and theaflavins assist healing of indomethacin. That is, the gross ulcer index in a 1yearold rat treated with indomethacin was significantly higher than that in a 7weekold rat p and ibuprofeninduced gastric ulcer. Most medical treatments are always time consuming and not efficient or satisfactory to the patients. Tibh against hclethanol induced gastric ulcer in rats. The stomachs were examined for ulcer with the aid of a magnifying lens x10. Leukotriene b4 in gastritis and peptic ulcer the mini. Peptic ulcer disease american college of gastroenterology. Indomethacin is a nonsteroidal antiinflammatory agent nsaia with antiinflammatory, analgesic and antipyretic activity.
Protective effect of ascorbic acid and ranitidine on the. Indomethacin helps relieve pain and inflammation by blocking the effects of the enzymes cyclooxygenase cox1 and cox2. Extensive use of nonsteroidal antiinflammatory drugs nsaids and alcohol, in addition to stress, are all predisposing factors for ulcers. M department of physiology, college of medicine, university of ibadan. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Oecd 2002 organization for economic cooperation and development guideline no. Assessment of protective effects of extracts of zingiber. We reported that the daily administration of cortisone, aspirin, or indomethacin to rats with this ulcer for 1. Comparison of indomethacin, diclofenac and aspirininduced. Effects of diacerein on indomethacininduced gastric ulceration. Gastric and duodenal antiulcer effects of aqueous bark. For patients who have persistent night pain or morning stiffness, a larger portion of the total daily dose up to 100 mg orally or. Delayed healing of acetic acidinduced gastric ulcers in rats. The pyloric antral lesion may reach maximum size in 610 hours, penetrated muscularis mucosae within three days and remains for at least 7 days. The gross ulcer index and damage area increased with age in the presence of three nsaids p indomethacin induced gastric ulcer model, the treatments of the animals with emn at doses of 100, 300 and mgkg, p. The assessment was carried out by using ulcer index, ulcer score and histopathological studies of the specimens. An acetic acid ulcer induced in the rat stomach is a chronic gastric ulcer model that gradu ally diminishes in size and depth until 4 wk after the ulceration, but persists for up to 250 days 4,5. The differences in ulcer dose reported in this study and.
That is, the gross ulcer index in a 1yearold rat treated with indomethacin was significantly higher than that in a 7weekold rat p indomethacin induced gastric ulcer ulcer index 2900, was associated with a significant increase of tumor necrosis factoralpha and malondialdehyde, and significant decrease of the gastroprotective mediators prostaglandin e2, glutathione gsh and nitric oxide no compared with normal control. The mgb decreases hunger ghrelin and increases satietyfeeling. Enhanced antiulcer effect of pioglitazone on gastric ulcers. Ranitidine or clo was administered 30 min prior to each dose of cysteamine hydrochloride. These were proportionally increased in animals treated with indomethacin 10, 20, or 40 mgkg. Peptic ulcer disease and nonsteroidal antiinflammatory drugs ncbi.
Pdf protective effects of naringin in indomethacin. However, in the group given food during the latter 3 hours between 12 and 15 hours after the drug administration, the number of ulcers was significantly decreased compared with those in the group given food ad libitum or in the group given food during. Oct 18, 2008 despite the fact that dietary habits and lifestyles are incredibly advancing, gastric ulceration is still a terrible complaint. In the present study we investigate the protective effects of extracts of zingiber officinale and althaea officinalis on pyloric ligationinduced gastric ulcer in rats.
Based on their intensity, the ulcers were given scores as follows. Antral ulcer formation in fasted and refed hamsters the effect of indomethacin on prostaglandin pc gen eration in the antral mucosa the effect of pharmacologic agents on antral ulcer formation 6. These events may occur at any time during therapy and without warning. Nsaids drugs use in pain management have been linked with ulcer and employed in several animal experiments, but the ulcer dose has been conflicting. Pdf gastroprotective effect of aqueous extract of chamomile and. The gastroprotective effect of the crude methanol extract. The gastroprotective effects of minocycline may be due to its antisecretory, antioxidant and anti inflammatory action.
Despite the fact that dietary habits and lifestyles are incredibly advancing, gastric ulceration is still a terrible complaint. Interestingly, ukwe et al 2010 had in an earlier study, used 40mgkgbw of indomethacin to induce ulcer in rats. Effect of leaves and fruits of moringa oleifera on gastric. This prevents prostaglandin synthesis prostaglandins elevate body temperature and make nerve endings more sensitive to pain transmission. Biochanin a gastroprotective effects in ethanolinduced. Furthermore, the poor gastric ulcers observed at dose 30mgkg and the very severe gastric ulcers at 50mgkg may be explained by the fact that usually, dosage determines effects. Gastroprotective mechanisms of imipramine on indomethacin. Mouth ulcers is found among people who take indomethacin, especially for people who are male, 5059 old, have been taking the drug for indocin recommended neonatal dose, route, and interval a.
A daily dose of a proton pump inhibitor is the most effective method of reducing the risk of ulcers induced by nonsteroidal antiinflammatory. Thank you for your interest in spreading the word about the bmj. Gastroprotective effect of garlic in indomethacin induced. Gastric ulcer is one of the most gastrointestinal disorders in world. Peptic ulcer is one of the most important and common disorders of the alimentary.
Benzohydrazide in hclethanolinduced gastric international. Duodenal ulcer was induced by administering cysteamine hydrochloride 400 mgkg, p. It is important to know that there are many causes of abdominal pain, so not all pain in the abdomen is an ulcer. Although alcohol has been shown to induce damage to the gastric mucosa in. Research paper article pdf available in british journal of pharmacology 1593. Indomethacin has been associated with rare cases of idiosyncratic drug induced liver disease. Different mechanisms in formation and prevention of. However ranitidine ulcer score was to be more potent p indomethacin induces gastric injury by inhibiting the release of cox1, pge2, and mucus. Nebivolol prevents indomethacininduced gastric ulcer in. Wistar rats were pretreated with esomeprazole reference drug at a dose of 20 mgkg body weight, s. Gastric ulcer was induced by injection of indomethacin 25 mgkg. Antiulcerative effect of dexamedetomidine on indomethacininduced gastric ulcer in rats. Gastroprotective mechanisms of imipramine on indomethacin induced gastric ulcer in male wistar rats oluwole, f.
Protective pathways and antisecretory mechanism article pdf available march 2017 with 389 reads how we. Gastric secretion and acidity studies were performed in pylorus ligated rats while indices of gastric ulcers were measured in ethanol 1 ml100% and indomethacin 30 mgkg, induced gastric ulcers. Original article gastroprotective effect of minocycline in. Polat b, albayrak y, suleyman b, dursun h, odabasoglu f, yigiter m, halici z, suleyman h.
Antiulcer effects of alpha lipoic acid on gastric acid. Based on this objective, three varying doses 30, 40 and 50. This study was designed to determine the effect of pretreatment with pioglitazone, the specific pparg ligand, on the gastric lesions induced by ethanol in cirrhotic rats. Pda closure dose mgkg age at 1st dose 1st 2nd 3rd 7d 0. Indomethacin became the firstchoice drug to produce an experimental ulcer model as a result of having a higher ulcerogenic potential than other nonsteroidal antiinflammatory drugs nsaids. Pdf this study was carried out to investigate the gastroprotective effect of aqueous extract of chamomile. The alcoholic extract of leaves of artocarpus heterophyllus lam. Protective effect of vitamin e on indomethacin induced.
There have been several conflicting reports about the ulcerogenic. Pdf different mechanisms in formation and prevention of. Request pdf nebivolol prevents indomethacininduced gastric ulcer in rats gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. To integrate the realization that peptic ulcer most commonly reflects infection with helicobacter pylori or use of aspirin and other nonsteroidal antiinflammatory drugs nsaids into a disease management approach. The protective effect of testosterone on indomethacin induced. The pathogenesis of gastric ulcer include several factors. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Rats of female sex weighing between 150 g 200 g were used. There are many drugs used for the treatment of gastric ulcer, but most of these associates with several adverse effects. He used this term for protection of experimentally induced gastric ulcer by prostaglandins 1.
The gross ulcer index increased with aging in rat treated with all three kinds of nsaids fig. The journal of biological chemistry 2003 by the american. The healing activities of black tea bt and the theaflavins tf against the indomethacin induced stomach ulceration were studied in a mouse model. Gastroprotective mechanisms of imipramine on indomethacininduced gastric ulcer in male wistar rats oluwole, f. Effect of ethanolic extract of coconut cocos nucifera on aspirin. In this regard, an animal model experiment was carriedout to determine the ulcer dose of indomethacin on female wistar rats.
Nonsteroidal antiinflammatory drugs nsaid such as indomethacin are widely used in the treatment of pain, fever and. Ethanol induced gastric ulcer gastric lesions were carried out according to adaptation of the method suggested by robert et al. This study investigates the effect of testosterone on indomethacin induced gastric ulcers in adult female rats. Moringaceae on gastric and duodenal ulcers was evaluated by using different gastric ulcer models and cysteamine induced duodenal ulcer method. The aim of this work was to study the possible protective effects of vitamin c and ranitidine on the gastric lesion induced by indomethacin in adult albino rats. Ulceration was induced by a single oral administration of indomethacin 30 mgkg body weight. Although gastric ulcer patients show normal or reduced level of acid secretion, duodenal ulcer patients usually secrete more acid 9, 10. The sum of the scores were divided by 10 the magnification of the lens to obtain the ulcer index for each rat main and whittle, 1975. We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. The volume of secretion is also an important factor in the formation of ulcer due to exposure of the unprotected lumen of the stomach to the accumulating acid 15, 19.
Pdf this study investigated the gastroprotective effect of lcarnitine against indomethacin induced gastric ulcer in rats and the possible mechanisms. The major side effect limiting its clinical use is the gastric damages. Also, males are known to be more exposed to ulcer risk factors. Gastroprotective effect of vanillin on indomethacininduced gastric ulcer in rats. The mini gastric bypass mgb is low risk, has excellent long term weight loss, minimal pain and can be easily reversed or revised. Ulcers can develop in the esophagus, stomach or duodenum, at the margin of a. Antiulcerogenic mechanism of magnesium in indomethacin. Nsaidinduced gastric damage according to age in rats 211 ity,17,22 and reduced blood flow.
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